Abstract. The successful development of the Russian economy and regions in the conditions of modern market economy is largely determined by the WHO-action control on the process at all levels of economic activity. From this point of view in the present study we examine the theoretical, methodological and practical provisions of the management system creating by sustainable development of the economy, both at the country level and in a separate region. In this aspect, in particular, it is noted that the current management of the economy of the region largely departs from the principles and provisions of the modern theory and best practices. On the other hand, complication and some changes are taking place in external and internal operation environment and enterprises development, industries, complexes and the region as a whole. These provisions stipulate the increasing importance of a new management system formation at all levels of regional economy, providing timely and continuous adaptation to external conditions. Under this approach to the management formation of the sustainable economic development it is necessary to improve the scientific basis, including the ways and instruments of control influence on the process.